Amiodarone is a commonly used anti-arrhythmic agent, with well-recognized lung toxicity. Such adverse effect is usually related to the dose and duration of the treatment, although there are reports showing that these are not the only predictors of toxicity. Following the occurrence of five cases diagnosed in a short period of time at the Serviço de Pneumologia do Hospital São Lucas da PUCRS, we reviewed clinical criteria and diagnostic procedures to assess such clinical situation. We conclude that is necessary a high clinical suspicion rate and for the need of pulmonary function evaluation, including carbon monoxide diffusion capacity, in all patients using the drug. Spirometry and arterial blood gases are useful only in severe cases.

Key words: Amiodarone; Anti-arrhythmic Agent; Pulmonary Toxicity.